Conventionally citrullus colocynthis fruits are used in antidiabetic treatment in mediterranean countries. Compound 1 possesses an unprecedented 2,11lactone moiety, while. While every effort has been made to provide the most reliable and uptodate information available, ultimate legal requirements with respect to species are contained in. Itis taxonomy is based on the latest scientific consensus available, and is provided as a general reference source for interested parties. Citrullus colocynthis on integrated taxonomic information system. The article also presents some of the functions of the chemicals present and attempt to emphasize and create an awareness of the great potential of citrullus colocynthis as a source of novel. Several studies on this plant reported and focused on the biological and toxicological profile of fruits pulp. Autecological studies on citrullus colocynthis species in saudi arabia najat a. Antioxidant activity of citrullus colocynthis pulp extract in the rbcs of alloxaninduced diabetic rats dallak m, binjaliah i department of physiology, college of medicine, king khalid university, abha, aseer, saudi arabia background.
Four ringa secocucurbitane triterpenoids, colocynthenins ad 14, together with seven known cucurbitane triterpenoids 511, were isolated from the fruits of citrullus colocynthis. Phenolic compounds and antiradical properties of methanolic extracts of citrullus colocynthis and plantago major in iran afsaneh moslemi mehni 1, fatemeh shahdadi 2 1young researchers and elite club, jiroft branch, islamic azad university, jiroft, iran 2department of. The fruit of citrullus colocynthis has been studied extensively for its wide range of biological. Citrullus colocynthis in the germplasm resources information network grin, u. Citrullus colocynthis, also known as bitter cucumber, is a fruitbearing plant sometimes used medicinally. Based on the above findings, the researchers agreed that citrullus colocynthis is suitable for use as an antiinflammatory agent. Four patients with colocynth intoxication are presented. Due to inconsistencies between the drug labels on dailymed and the pill images provided by rximage, we no longer display the rximage pill images associated with drug labels we anticipate reposting the images once we are able identify and filter out images that do not match the information provided in. The main clinical feature was acute rectorrhagia preceeded by mucosal diarrhea with tenesmus, which gradually progressed to bloody diarrhea and overt rectorrhagia within 3 to 4 hours. Citrullus colocynthis is a folk medicinal plant of saudi arabia. The present study reveals the medicinal uses, chemical compositions and examines recent investigations on the therapeutic activities of extracts and chemicals identified from citrullus colocynthis. Cocyntal activated charcoal, citrullus colocynthis. Out of scope information includes radiopharmaceuticals, contrast media, herbals, homeopathics, and food. Extraction and characterization of citrullus colocynthis oil.
Previous studies in our laboratory showed that citrullus colocynthis pulp seedless extract. Toxic effect of citrullus colocynthis on liver ijpt. There have been reports of death following ingestion of just 112. Citrullus colocynthis, cucurbitaceae, indravaruni, bitter apple. Germplasm of citrullus colocynthis in the united arab emirates was studied to find variation in it. Chemical constituents and pharmacological effects of. These plants have lemonsized fruits which are known for their medicinal properties. Persons familiar with the common watermelon vine need no description of the plant which produces colocynth apples.
This page was last edited on 24 november 2014, at 11. Effects of alkaloid rich extract of citrullus colocynthis. The bitter apple is a vinelike plant commonly found in asia and the mediterranean basin. Transesterification of citrullus colocynthis thumba oil. Effects of alkaloid rich extract of citrullus colocynthis fruits on artemia salina and human cancerous mcf7 and hepg2 cells aniruddha mukherjee, savita d patil abstract in the present research the anticancer effect of alkaloid rich extract of citrullus colocynthis fruits.
Sufficient amount of citrullus colocynthis fruits were prepared and dissolved in 80 methnol and prepared in ointment baseat 80% concentration. Citrullus colocynthis is used to treat diabetes, since it may be able to induce insulin secretion from the pancreas after supplementation, while reducing blood glucose and improving lipid levels. The word citrullus is the diminutive of the greek word citrus. Effects of hydroethanol extract of citrullus colocynthis. Citrullus colocynthis as the cause of acute rectorrhagia. Bitter apple common names bitter apple trees are also known by a host of common. Citrullus colocynthis is used to treat diabetes, since it may be able to induce insulin secretion from the pancreas after supplementation, while. Schrad is a valuable cucurbit plant, widely distributed in the desert areas of the world. Enhancement of callus induction and cucurbitacin content. Cucurbitacins from the leaves of citrullus colocynthis l. All structured data from the file and property namespaces is available under the creative commons cc0 license. Citrullus colocynthis, cucurbitacins, cytotoxicity. The effect of citrullus colocynthis extract on cutaneous.
New state records for citrullus, cucumis, and cucurbita cucurbitaceae outside of cultivation in the usa. Attention as a natural insecticide and its activity has been evaluated against. Fifty rats were randomly divided into five groups 4 experimental and 1 controls. Effect of the rootknot nematode meloidogyne incognita and the fruit extract of citrullus colocynthis on chlorophyll content a, b and total mgg of fr. Physiological effects of allelopathic activity of citrullus colocynthis on vicia faba and hordeum vulgare hediat m. Citrullus colocynthis fruits are usually recognized for its wide received in revised form range. Citrullus colocynthis extracts insecticidal activity pdf. Their structures and absolute configurations were elucidated based on spectroscopic analysis and quantum chemical ecd calculations. Files are available under licenses specified on their description page.
Autecological studies on citrullus colocynthis species in. These compounds include elatermidine, glycosides, resin, dihydric alcohol, heltiacontane, citrullin and citrullinic acid. It was banned by the food and drug administration in 1991 taking even very small amounts of colocynth can cause severe irritation of the stomach and intestine lining, bloody diarrhea, kidney damage, bloody urine, and inability to urinate. Screening of antioxidant potential of methanolic extract. Why is dailymed no longer displaying pill images on the search results and drug info pages. Pdf the present study reveals the medicinal uses, chemical compositions and examines recent investigations on the therapeutic activities of. Citrullus colocynthis an overview sciencedirect topics. Enhancement of callus induction and cucurbitacin content in citrullus colocynthis l. Citrullus colocynthis is a very droughttolerant medicinal species, closely related to watermelon c.
Citrullus colocynthis supplement health benefits, dosage. The fruit pulp of colocynth has medicinal properties while the seeds have nutritive qualities. Citrullus colocynthis is a medicinal plant that has anticancer property mediated by apoptosis. Cocyntal activated charcoal, citrullus colocynthis fruit, copper liquid out of scope out of scope for rxnorm and will not receive rxnorm normal forms. Schrader cucurbitaceae family is a fruit commonly known as bitter apple or bitter cucumber, found in sudan, iran and india.
Citrullus colocynthis contained carbohydrate, protein, separated amino acid, tannins, saponins. Despite its promise for the food industry, it is the smallscale, subsistence use that most concerns us here. Colocynthis homaccord fda prescribing information, side. Twenty five different accessions of the species were collected. Report by journal of the alabama academy of science. To evaluated the differential effects of ethanol extraction of citrullus colocynthis c. Taking even very small amounts of colocynth can cause severe irritation of the stomach and intestine lining, bloody diarrhea, kidney damage, bloody urine, and inability to urinate. Science and technology, general agricultural chemicals antimitotic agents antineoplastic agents fertilizers research food additives germination liquid chromatography phytochemicals plant. The present study was performed to determine the efficacy of citrullus colocynthis on cutaneous leishmaniasis lesion in human. Citrullus colocynthis in saudi arabia source migahid, 1996.
Citrullus colocynthis extracts insecticidal activity pdf abstract. Colocynth definition of colocynth by the free dictionary. Cphydroxybenzoylglycoflavones from citrullus colocynthis. The present study focused on the cytotoxic and genotoxic potency of aqueous leaves extract of this plant. The citrullus colocynthis extract significantly lowered the formation of granuloma tissue in chronic inflammation model. As already mentioned, that flour enriches and thickens soups as well as other foods.
Ibhrahim1 department of botany and microbiology, college of science, king saud university. Citrullus colocynthis cct, also known as bitter apple, wild gourd, tumba and wine of sodom, is known for its medicinal value since long. The fruit pulp of colocynth has medicinal properties while the seeds. The leaf extract of two cucurbitacious plants citrullus colocynthis and cucurbita. Known hazards the plant contains a number of potentially toxic compounds and can be harmful if used in quantity.
In the experimental groups a single daily dose of alcoholic extract of citrullus colocynthis 50, 100, 200, 400 gkg was administered intraperitonally. It was banned by the food and drug administration fda in 1991. Screening of antioxidant potential of citrullus colocynthis methanolic extract sudhanshu 1, nidhi rao 1 sandhya mittal 1 and ekta menghani 2 1suresh gyan vihar university, jaipur 2mahatma gandhi institute of applied sciences, jecrc campus, jaipur22. Colocynthenins ad, ringa secocucurbitane triterpenoids. There have been reports of death following ingestion of just. Other side effects include convulsions, paralysis, and death. Citrullus colocynthis fruits were extracted by different solvents nhexane. Citrullus colocynthis was reported in multiple ethnopharmacologic studies from different part of the world as a traditional remedy for a variety of diseases including gastrointestinal, musculoskeletal, neurological, cardiovascular, and respiratory disorders also, diabetes mellitus is known as the most popular traditional indication of c. Sollmann t 1957 a manual of pharmacology and its applications to. Watermelon, wild watermelon, egusi melon, west african watermelon, dessert watermelon, cooking melon, fodder melon, preserving melon, citron, melancia portuguese, pasteque french 1,6,8,9 etymology. Bitter apple scientific name the scientific name for this plant is citrullus colocynthis. Citrullus colocynthis fruits are usually recognized for its wide range of medicinal uses as well as pharmaceutical and nutraceutical potential. This research discussed an analytical study of citrullus colocynthis plants oil, where. Department of agriculture agricultural research service.
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